Pepperoni Pizza Bubble Up Casserole

A delicious, cheesy pizza casserole made with fluffy biscuit dough, rich pizza sauce, gooey mozzarella cheese and mini pepperoni! Everything comes together in one baking dish for an easy family dinner that tastes just like pepperoni pizza.

Prep time: 10 minutes
Cook time: 25–30 minutes
Total time: 40 minutes
Servings: 6–8

1. Ingredients

IngredientQuantity
Refrigerated biscuit dough (Grands-style)1 can (16.3 oz / 460 g)
Pizza sauce or marinara sauce1½ cups
Shredded mozzarella cheese2 cups
Grated Parmesan cheese¼ cup
Mini pepperoni1 cup
Italian seasoning1 tsp
Garlic powder½ tsp
Olive oil or cooking sprayFor greasing

Optional: Add diced green bell peppers, mushrooms or black olives.

2. Step-by-step instructions

Step 1 – Prepare the oven

Preheat your oven to 375°F (190°C).

Lightly grease a 9 × 13-inch baking dish with cooking spray or olive oil.

Step 2 – Cut the biscuits

Open the refrigerated biscuit dough and separate the biscuits.

Cut each biscuit into 4 equal pieces to create small dough bites.

Step 3 – Prepare the pizza mixture

In a large mixing bowl, combine the pizza sauce, garlic powder and Italian seasoning.

Add the biscuit pieces and gently toss until all the dough pieces are coated with sauce.

Step 4 – Assemble the casserole

Transfer the coated biscuit pieces into the prepared baking dish.

Spread them evenly so they form a single, relatively even layer.

Step 5 – Add the cheese

Sprinkle 1½ cups of shredded mozzarella over the biscuit pieces.

Add half of the mini pepperoni and sprinkle with Parmesan cheese.

Step 6 – Add the remaining toppings

Sprinkle the remaining mozzarella cheese and mini pepperoni evenly over the top.

Add a little extra Italian seasoning if desired.

Step 7 – Bake

Place the casserole in the preheated oven.

Bake uncovered for approximately 25–30 minutes, until the cheese is melted and bubbly and the biscuit pieces are golden and fully cooked in the center.

If the cheese starts browning too quickly, loosely cover the dish with aluminum foil.

Step 8 – Rest and serve

Remove from the oven and let the casserole rest for 5 minutes.

Sprinkle with additional Parmesan or fresh parsley if desired.

Serve warm while the cheese is deliciously melted and stretchy!

3. Delicious variations

  • Supreme pizza: Add mushrooms, green peppers, onions and black olives.
  • Meat lovers: Add cooked sausage, bacon and extra pepperoni.
  • Extra cheesy: Add cheddar or provolone along with mozzarella.
  • Spicy pizza: Add red pepper flakes or spicy pepperoni.
  • Vegetarian: Replace pepperoni with mushrooms, peppers, olives and onions.

4. Tips for the perfect pizza casserole

  • Cut biscuits into similar-sized pieces so they cook evenly.
  • Don’t overcrowd the baking dish.
  • Use pizza sauce rather than too much watery tomato sauce.
  • Make sure the center biscuit pieces are fully cooked before removing the casserole from the oven.
  • Let the casserole rest before serving so the cheese and sauce settle.

5. Storage instructions

  • Refrigerator: Store leftovers in an airtight container for up to 3–4 days.
  • Freezer: Freeze cooked portions for up to 2 months for best quality.
  • Reheating: Reheat in the oven at 350°F (175°C) until heated through, or microwave individual portions.

Easy family dinner!

Golden biscuits, rich pizza sauce, loads of melted mozzarella and crispy mini pepperoni in every bite! ❤️🍕

Recipe note: The image doesn’t show exact measurements, so these quantities are a suggested version based on the ingredients and preparation pictured.